The best quality Russian Taxifolin (dihydroquercetin). We produce and sell directly high quality Taxifolin from science city Pushino near Moscow. Made of ecologically pure Siberian larch.
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Highly purified taxifolin /dihydroquercetin (till 99,5%) from Siberian larch from ecologically pure region of Russia for export in the powder and in the form of premixes (solutions) for any medical, health, healthcare and industrial use!
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The "FLAVIT" company offers at
prices manufacturers powerful natural antioxidant
which is called in the West, Taxifolin, of vegetable origin, made
from the butt of Siberian
larch growing in
environmentally clean areas of lake Baikal,
a purity of up to 99.5% of the wholesale and
retail, for individuals and
organizations in the form of dietary SUPPLEMENTS,
solutions, healing, suspensions, as well as
containing dihydroquercetin creams, skin
As well as high-purity dihydroquercetin in powder and in the form of premixes (solutions) for industrial use.
is obtained from Siberian larch patented an
innovative method was developed by leading scientists biologists of Moscow state University. University.
Eliminates the violation of the natural - native properties of TAXIFOLIN. The higher purity of the drug at least 98.6% (99,3%-99,5%), with maximum antioxidant activity - 38 000 - 42 000 ORAC units, no side effects (over 40 years of clinical research and testing), confirm reference the properties of our TAXIFOLIN is produced under the trademark "Taxifolia - plant of new generation.
For what need TAXIFOLIN to the body?
The answer is simple - for a long healthy active life.
TAXIFOLIN is a scavenger of free radicals formed in the process of life processes constantly taking place in our organism, and under the influence of adverse environmental factors (deteriorating ecology, contaminated water, air, microwave radiation, etc.).
TAXIFOLIN protects the cells of our body from premature aging mutation (cancer degeneration).
Many years of clinical studies proved the high efficiency of dihydroquercetin as a soft, highly - effective bioregulator broad spectrum.
In this regard, very promising:
- Cardiovascular diseases,
- Broncho - pulmonary diseases,
- Diabetes and its consequences
- Peptic ulcer disease,
- Diseases of the liver and pancreas,
- Allergic diseases,
- Eye diseases,
- Immunodeficiency diseases
- Bacterial and viral diseases,
- Withdrawal radionuklidov,
- Intoxication with food poisoning
- The improvement of cerebral circulation (nootropic properties)
- Facilitates the condition of patients sclerosis, Alzheimer's and Parkinson's, etc.
Not being a dope, enhances strength and power athletes, divers, etc..
You may doubt that this can not be!
TAXIFOLIN is certainly not a panacea, but numerous studies Russian and foreign scientists has proved the positive influence of TAXIFOLIN on the body in all situations.
TAXIFOLIN / Dihydroquercetin
Dihydroquercetin (dihydroquercetin) Chemical name: 3,5,7,3',4'-Penta-hydroxyflavanone
(international nonproprietary name TAXIFOLIN )
(CAS No. 480-18-2) - reference antioxidant bioflavonoid drug of vegetable origin, obtained from Siberian larch wood (Larix sibirica Ledeb.) or Dahurian larch (L. dahurica Turcz.) by water-alcohol extraction and further purification using chromatography.
Numerous studies have found that dihydroquercetin (Taxifolin he) provides vitamin, angioprotective, antioxidant, detoxification, hepatoprotective (toxic), radioprotective and anti-edema properties; stimulates the regeneration of the gastric mucosa. Prevents lipid peroxidation of cell membranes, protects blood vessels from damage, reduce swelling inflammation, has hypolipidemic and diuretic activity.
Dihydroquercetin is an effective antioxidant which interrupts the process of lipid peroxidation in cell membranes, is able to penetrate into the cytoplasm of the cell and protect the cell from damaging effect of free radicals, effectively corrigiruet violations in various components of antioxidant system of the body. Provides comprehensive antioxidant protection, active prevention of the development of oxidative stress, degenerative-dystrophic processes in tissues and early cellular aging, can effectively counteract the destructive factors of modern ecology, production, nutrition and lifestyle.
#Dihydroquercetin has a synergistic effect against ascorbic acid and, most importantly, the membrane antioxidant vitamin E, helping (especially in combination with ascorbic acid), regeneration of the active form of the latter and preventing the formation of tocopherylquinone.
Anti-inflammatory activity of Taxifolin due to its antioxidant effect and inhibitory effect against enzymes (enzymes) produced during inflammation and the subsequent inhibition of production of inflammatory mediators, and modulating its regulatory effect on key functional systems of cells, organs and tissues of the body, including antioxidant system of cells and tissues; enzymes, including representatives of almost all classes and groups of enzymes (oxido–reductase, hydrolase, lyase, transferase, kinase); receptor apparatus of cells and intracellular information system; systems of ion transport and ion homeostasis of the cell.
Dihydroquercetin helps to regulate overly active immune system by reducing the level of factor-alpha tumor necrosis, interleukin-1 beta, interleukin-6. Dihydroquercetin helps to reduce the damaging effect of hydrogen peroxide (H2O2) on epithelial cells of respiratory system, helps to reduce the activation of nuclear factor-KB (NF-KB), prevents the effect of stress on auxiliaries polimorfnoyadernami neutrophils, alveolar macrophages and fibroblasts. Suppressing molecules of dihydroquercetin and its metabolites enzymes of the arachidonic acid metabolism of cyclooxygenase and lipoxygenase, controlling the formation of inflammatory factors and allergies, determines the anti-inflammatory and antiallergic properties of dihydroquercetin and its metabolites.
In redox regulation of the cell transcription dihydroquercetin supports the protective action of enzymes of the fermentative link of the antioxidant system of the cells, in particular, enzymes the first line of antioxidant defenses (peroxidases, catalase, etc.). Ingredient exhibits an indirect antioxidant effect, capable of activating (or stimulate) the enzymes of the 2nd phase of detoxification in the liver, which act as a defense mechanism, triggering broad spectrum antioxidant processes, preventing the damage of cells. The effect of indirect antioxidant action of dihydroquercetin is retained even after its elimination from the body, in contrast to the direct antioxidant action of ingredient.
Dihydroquercetin inhibits the enzymatic reactions that are produced by the superoxide radical and peroxide radical (e.g., xanthine oxidase, peroxidase the activity of which increases significantly during ischemia, NADP oxidase, the activity of which activates the inflammatory factors oven activity, etc.).
The influence of dihydroquercetin on the receptor apparatus of cells combined with the impact on the function of enzymes controlling signal and the actuators of the cells, phosphodiesterase, protein kinases, which determine the mechanisms and nature of the cellular response to the effect of hormones and other signaling molecules, and drugs — agonists and antagonists of cellular receptors. Dihydroquercetin has a unique transcriptional signal status and redox regulation of cellular transcription, capable of modulating the activity of protein tyrosine phosphatase and thioredoxin, who have an active terminal buds gesteine in the thiol form, as well as the activity of transcription factors AP-1 and NFκB cascade, and several other factors, all of which have redox-sensitive gistaminovye ends in thiol form. Dihydroquercetin is demonstrating its modulating activity when the receptor stimulates the production of peroxide (H2O2) leads to the activation of all mitogen-activated protein kinases (ERK, JNK, and p38 MAPK). The last enzyme is activated by sequential phosphorylation, which in turn regulates the activity disrelish transcription factors and/or other kinases, controlling the expression of certain genes and as a key element in the mechanism of cytokine-dependent and stress-induced apoptosis. Modulation dihydroquercetin induced the expression of the protein ICAM-1 - intercellular adhesion molecule 1 (molecule of the endothelial cells) is set at the transcriptional level by inhibiting the activity of signal transducers and activators of transcription (STAT)1 and protein tyrosine phosphorylation of Janus kinase 1. Relevant signaling pathways (JAK-Stat) are molecular action application of dihydroquercetin;
With an inhibitory effect of dihydroquercetin on some forms of protein kinase is associated With regulation of activity of some membrane enzymes, ion transport (Ca2+- and Na+-K+ - ATPase), a metabolic enzyme systems (e.g. cytochrome P–450, phospholipase, lipase, etc.), functioning of the parts of the endocrine, immune system, blood cells. Dihydroquercetin prevents the increase in permeability to calcium ions, the second result of lipid peroxidation connected with the fact that the products of peroxidation have the ability to directly increase ion permeability of the lipid bilayer. Dihydroquercetin prevents the inactivation of the ion-transport enzymes, the active site which contain thiol groups, primarily Ca2+-ATPase. The negative effect of inactivation of this enzyme is reduced in the "pumping" calcium ions out of the cell and, on the contrary, increasing calcium entry into the cell, increase the intracellular concentration of calcium ions and cell damage. Dihydroquercetin prevents oxidation of thiol groups of membrane proteins, which can lead to the appearance of defects in the lipid layer of cell membranes and mitochondria.
Dihydroquercetin has capillarization effect, reduces the permeability and fragility of capillaries, improves microcirculation, contributes to the inhibition of enzyme activity of hyaluronidase and collagenase, which loosened the connective tissue of blood vessel walls and other systems, but activates prolylhydroxylase that contribute to the "maturation" of collagen (the synergy of action of dihydroquercetin in the ratio of ascorbic acid – substrate prolylhydroxylase), thus supporting the strength, elasticity and normal permeability of the vascular wall. Dihydroquercetin inhibits free radical processes of lipid peroxidation in biomembranes (breaks the chain of interaction between the hydroperoxide and nitrophenoxide with lipids and lipopolysaccharide), stabilizes cell membranes, helps normalize the permeability of capillaries, prevents the development of dystrophic and sclerotic changes in tissues. At the water-lipid surface of cell membrane, structure, number and location of hydroxyl groups of molecules of dihydroquercetin with a predominance of hydrophilic groups, determine the formation of hydrogen bonds with the polar external groups of the lipid molecules of the membrane, thereby protecting the membrane from external damage.
Dihydroquercetin has a positive effect on the molecular mechanisms underlying the regulation of vascular permeability and resistance of the vascular wall, but also affect the arachidonic metabolism, which allows the use of dihydroquercetin in inflammatory diseases, allergic and hemorrhagic syndromes, radiation injuries. The influence of dihydroquercetin on the activity of related enzymes in a complex with antioxidant action determines its capillary stabilizing effect (associated with P–vitamin activity), impact on resistance and vascular permeability, deformability (elasticity) of red blood cells.
Positive pharmacological properties of dihydroquercetin are shown both in the intracellular and outside the cell environment. Studies on erythrocytes, leukocytes, macrophages and hepatocytes have shown that dihydroquercetin contributes to their greater resistance to membrane damage. Dihydroquercetin contributes to the inhibition of expression of adhesive proteins, called gamma interferon, thus exerting a modulating effect on the processes of coagulation and adhesion. Dihydroquercetin supports the inner walls of blood vessels and capillaries from the effects of destructive enzymes, decay and free radical damage
TAXIFOLIN / Dihydroquercetin in SPORT
From the amiable agriment of companies "FLAVOMIX" (Russia) & "TAXIFOLIA"(Russia)
Taxifolin (Dihydroquercetin) —
new possibilities in sports nutrition
Performance and endurance training, required in professional sports, is closely related to the training of one’s cardiovascular system in order to adapt it to exercise workload. This is especially important during the competition period, when physical demands are at their peak and athletes strive to push their limits.
An individual, undergoing intense physical training, utilizes oxygen at levels exceeding 75% of maximum values. The challenge here is that sustained physical exercise may result in an inadequate supply of oxygen to working muscles (known as tissue hypoxia), a result of insufficient blood supply to the tissues due to poor microcirculation.
Moreover, during maximal exercise, the metabolism of the tissue is violated. Muscles accumulate lactic acid, which causes fatigue and complicates recovery after training.
Studies show that the application of taxifolin is able to solve these problems very efficiently. Specifically, taxifolin is able to:
- Improve intracardial hemodynaimcs and intensify blood flow to the myocardium
- Help to return pathologic microcirculation to normal, thus, optimizing tissue blood flow
- Contribute to the redistribution of blood flow within small arteries, thus, enhancing blood supply to ischemia-affected tissues
- Enhance blood flow to muscles
- Enhance pulmonary mechanics and improve lung ventilation and blood gas composition
- Help to increase РО2 (oxygen partial pressure) and blood oxygenation
Studies of taxifolin were conducted during the training period of the Russian Olympic Team prior to the 2008 Olympic Games. The studies were supervised by S. A. Parastaev, M. D., a member of the medical commission of the Russian Olympic Committee, Professor of Physical Therapy, Sports Medicine, and Physical Education of the Russian State Medical University.
The studies showed that taxifolin can be utilized by professional athletes in daily doses of up to 100-200 mg during the training period, which requires aerobic and anaerobic endurance, as well as during the competition period when the workload is at its maximum.
We provide our own methods of qualitative and quantitative testing of taxifolin in premixes and in any type of end products. End product control is performed utilizing ultraviolet spectrophotometry and high performance liquid chromatography (HPLC) subject to the state reference standard (GSO No. 9054-20080).
Federal State Educational Institution of Higher Professional Training
RUSSIAN STATE UNIVERSITY OF PHYSICAL EDUCATION, SPORT AND TOURISM (RGUFKSMIT)
Sport Research Institute
Effect of Taxifolin (Dihydroquercetin) on physical work capacity in top athletes practicing cyclic sports
Project Director S.K. Sarsania, M.D., Prof.
Topicality of the research. Professional sport training and participation in competitions involve strenuous efforts and constantly growing training loads to be executed by athletes. For this reason we feel the need to detect and investigate specific factors, which may help improve physical work capacity in top athletes and speed up the recovery after training exertion. On the one hand, these factors are related to optimal planning of both competition and training loads according to biological adaptation laws with the use of pharmacological support. On the other hand, these factors comprise efficient recovery of the organism after physical training. The recovery process is based on well-balanced nutrition and intake of food supplements of high biological value and high metabolic capacity, which intensify the synthesis of morphological structures and activate favourable physiological reactions. In a long list of biologically active additives, we found it interesting to study a product with the trade name Taxifolin, chemical name (Dihydroquercetin)-98%, produced by the company "Taxifolia" Ltd., Belgorod (Registration #22.214.171.124.У.7914.8.09; date of registration 24.08.2009). A preliminary information study showed that this product might be called a model antioxidant free of admixtures (pitches, essential oils), its purity being not less than 98%. The base substance is found in the bottom part of Siberian larch and Dahurian larch .
Principal properties of Taxifolin:
- improvement of microcirculation;
- preventing thrombus formation;
- enhancement of work capacity and intensification of recovery processes after high physical and psycho-emotional loads;
- strengthening of capillary walls;
- bringing triglycerides and cholesterol concentrations in blood to normal level;
Hypothesis. Taking into account the ability of Taxifolin to protect capillaries and improve microcirculation, we suggest that the use of Taxifolin increases oxygen supply and utilization in skeletal muscles, thus resulting in development of aerobic capacities and growth of results in endurance sports.
Purpose. The purpose of our research was to estimate short-term and long-term effects of Taxifolin intake on aerobic capacity of working muscles, functional capacity of the cardiovascular system, and short-term recovery after maximal physical exertion.
Subjects. 5 top-class male athletes (Masters of Sport; Masters of sport, International Class) participated in the research. The age of the subjects varied from 23 to 28 years; all the subjects have been practicing skiing, cycling, and mountain running for many years.
Object of investigation: aerobic capacity of skeletal muscles and functional capacity of the cardiovascular system.
1. estimate short-term adaptive effects of Taxifolin intake on 1) functional capacity of the cardiovascular system at rest and 2) immediate recovery of physiological parameters after physical exertion;
2. estimate long-term adaptive effects of Taxifolin intake on 1) functional capacity of the cardiovascular system at rest and 2) immediate recovery of physiological parameters after physical exertion;
3. estimate short-term adaptive effects of Taxifolin intake on aerobic capacity of skeletal muscles;
4. estimate long-term adaptive effects of Taxifolin intake on aerobic capacity of skeletal muscles.
Taxifolin is not dope.
Regular Taxifolin intake for 2-3 weeks helps to enhance aerobic capacity of skeletal
muscles in athletes practicing cyclic sports, as well as accelerates the recovery after
intensive muscular work. Taking into account all our research data, we may recommend
athletes to use Taxifolin as an effective and safe antioxidant, capillaries protector and
immunomodulator in sports, which require both local and global muscular endurance.
Taxifolin is especially useful in the periods of intensive training aimed at improvement of
skeletal muscles aerobic capacity.